منابع مشابه
On the toxic proteins abrin and ricin. Studies of their binding to and entry into Ehrlich ascites cells.
The mechanism of penetration of the toxic plant proteins abrin and ricin into Ehrlich ascites cells has been studied by measuring, under different experimental conditions, the lag occurring from the time the cells have been incubated with the toxins until protein synthesis in the cells is inhibited. When Ehrllch ascites cells were incubated with abrln or ricin at 37”, a lag time of at least 30 ...
متن کاملKinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells.
Kinetic parameters of the interaction of the toxic lectins abrin and ricin with human erythrocytes and HeLa cells have been measured. The binding of 125I-labeled abrin and ricin to human erythrocytes and to HeLa cells at 37 degrees was maximal around pH 7, whereas at 0 degrees the binding was similar over a broad pH range. The binding occurred at similar rates at 0 degrees and 37 degrees with r...
متن کاملThe Histological Changes Produced by Ricin and Abrin Intoxications
The study of the effects of the living pathogenic organisms upon the animal body has been succeeded by an era in which especial attent-ion has been directed to the influence of their soluble products. The researches of Oertel* upon human diphtheria, of Babes t and of Welch and Flexner$ upon the experimental form of the disease, the latter including the effects of the soluble products of the gro...
متن کاملPolyribosome disaggregation in rat liver following administration of the phytotoxic proteins, abrin and ricin.
As the possible mechanisms of inhibition of protein biosynthesis, it was demonstrated that the toxic proteins abrin and ricin cause the degradation of polyribosomes of rat liver or Ehrlich ascites tumor cells. Abrin and ricin have no direct effect on the structural and functional integrity of polyribosomes but act indirectly by increasing the RNase activity in the postmicrosomal supernatant fra...
متن کاملToxicity and detection of ricin and abrin in beverages.
The oral and intraperitoneal (i.p.) toxicities to female BALB/c mice of ricin and abrin in phosphate-buffered saline (PBS), spring water, apple juice, and half-and-half (only oral) were examined after brief (2 h) and prolonged (11 to 13 days) storage. The ricin and abrin samples prepared in PBS had oral toxicities consistent with those previous studies, indicating oral and i.p. 50% lethal doses...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42608-2